Factions are political groups that kindred fall into. Which group they choose to align with is determined either through their agreement with their culture, forced by their sires, or other factors contributing to which side they select. In modern nights, there are two prominent factions, either Camarilla or Anarch. Those who do not pick a side or join in with smaller lesser known groups are known as Autarkis. In the fifth edition, the Sabbat, have been decimated by their own actions and are an antagonistic faction left shattered.
- Main article: Camarilla
The Camarilla is one of the most organized and influential Kindred organizations in history. Their goal is to preserve the masquerade and keep Kindred in line with rules that help protect their society from the prying mortal eye. Beyond this, it is a conspiracy to help elders preserve their power built on an undead secret society that influences global business and politics. The Camarilla is the closest thing they have to a system of government and an international union of cities. It is completed by an inner circle and its Justicars and Archons that roam the world in order to "keep the peace". A fierce moral stance is held on preserving humanity even against the impulses of the Blood, seeing themselves as shepherds to the herds of mortals they blindly control. Many Camarilla members have a wealth of power and money, on top of their age and the inclusion of Anarch defects joining their ranks makes the sect distinctly upper class.
- Main article: Anarch
Originally called the Anarch Revolt, this sect is as old as the revolution against the Camarilla itself. In recent decades it has seen vast growth as younger kindred find it increasingly difficult to understand why they must follow the laws of elders who care nothing for them, but to throw them in harms way when needed. All vampires who fall outside of the Tower's control are considered "unbound", and the Anarch movement is a small but visible subsection of the unbound who, rather than hide, have decided to fight back. They fight to claim territory from those who oppress them, as the ancient hands that held onto it are disappearing due to the Beckoning or other outside forces.
The Autarkis are the kindred who remain unbound to political sects, either through refusal to allow other sects to move into their domain or by simple refusal to align themselves to any cause but their own. Their ambitions usually lie with protecting their own unlives or lineage, and they have little care for others. 
- Vampire: The Masquerade Corebook, page 56